Officials said he broke his right collarbone.
Later Saturday, Kentucky Derby winner Nyquist takes on 10 rivals in the Preakness Stakes.
The horse is being taken to New Bolton Center in Pennsylvania for an autopsy.
In the opening race, Homeboykris collapsed and died after his victory and having his picture taken in the winner's circle. He had just won his 14th race in 63 career starts.
Centeno was driven off in ambulance. Pimlico racing officials said the 4-year-old filly owned by Roy and Gretchen Jackson's Lael Stables was euthanized on the track after breaking her left front cannon bone.
Pramedya was bred and owned by the Jacksons.
. Track officials believe the 9-year-old gelding suffered cardiovascular collapse.
In 2006, Barbaro shattered bones in his right hind leg just after the start of the Preakness, survived surgery but developed laminitis and was euthanized in January, 2007.
Ten years after Kentucky Derby winner Barbaro broke down at fun788 the start of the Preakness, the owners of the ill-fated colt have had another horse die on a damp, rainy Saturday at Pimlico Race Course.
Homeboykris won the Champagne Stakes in 2009, and a year later finished 16th in the Kentucky Derby. It's the same animal hospital Barbaro was taken to after his injuries.
In a tragic start to Preakness day, two horses died and a jockey broke his collarbone in the first four races.
Pramedya broke down around the turn in the fourth race, tumbled to the turf as jockey Daniel Centeno was thrown to the ground